Human Milk: Understanding the Mechanisms Linked to the Prevention of Obesity and Diabetes in Children Exposed in Utero to Gestational Diabetes

Laval University60 enrolled

Overview

Breastfeeding has been associated with decreased obesity. However, this relationship is not as clear in children who have been exposed to GDM and the mechanisms involved are little known. The overall objective of the project is to study the mechanisms of breastfeeding on the growth of children in women who have had a GDM. More specifically, the project want to compare the macronutrient and hormone composition of breast milk of women with and without GDM. Investigators also want to associate the levels of hormones related to satiety and energy metabolism (i.e. endocannabinoids, ghrelin, leptin) in the human milk of women with or without DG and the growth of the child. A total of 60 women (30 with GDM and 30 without GDM) will collect breastmilk at 2 months postpartum.

Other data collected: Waist circumference, DXA, Fasted blood sample, Oral glucose tolerance test, Breastfeeding habits, Food habits, Baby's height et weight.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Gestational Diabetes

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Breastfeeding women Exclusion Criteria: * Type 1 or type 2 diabetes * Preterm birth * History of bariatric surgery * Multiple births

Locations (1)

Institut sur la nutrition et les aliments fonctionnels

Outcomes

Primary Outcomes

Study the mechanisms linked to the effect of breastfeeding on the growth of children in women who have had GDM.

Time frame: 2 years

Secondary Outcomes

Compare macronutrient and hormone composition of breast milk of women with and without GDM.

Time frame: 6 months

Associate level of hormones related to satiety and energy metabolism (i.e. endocannabinoids, ghrelin, leptin) in the human milk of women with or without GDM and the growth of the child.

Time frame: 6 months