The Eggs and actiVity in hEalth agiNg Pilot (EVEN-P) Trial in Older Persons

McMaster University

Overview

Two of the most effective lifestyle-based approaches to reduce the risk of adverse health events and enhance quality of life with aging are exercise and a healthy diet. Currently, the Canadian recommended dietary allowance (RDA) for protein is 0.8 g/kg/day, however, several expert groups have advocated for a higher RDA of protein (\~1.2 g/kg/day), along with more evenly distributed daily consumption, in older persons. Eggs are considered a nutrient-rich protein source but have recently been scrutinized. This study will compare a high-protein, egg-containing diet and a high-protein, non-egg diet in healthy older persons.

This study will examine the impacts of an egg-containing diet and a non-egg diet in healthy older persons. Briefly, participants (healthy persons, age 60-75 years old) will consume their normal diet or their normal diet plus 4 eggs completing a structured exercise program (designed to meet Canada's Physical Activity Guidelines) for a total of 12 weeks. Participants will be randomly assigned to the Egg or Control (non-egg) group. Before and after the 12-week intervention, participants' undergo assessments of diet-quality, muscle health, fitness, bone health, and vascular health.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Conditions

Aging

Interventions

ExerciseBEHAVIORAL

Participants will exercise in a supervised facility twice weekly and consume their habitual diet.

Exercise plus diet (egg)BEHAVIORAL

Participants will exercise in a supervised facility twice weekly and consume an addiitonal 4 eggs per day.

Eligibility

Sex: ALLMin age: 60 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Exclusion Criteria: 1. Use assistive walking devices (e.g. cane or walker) 2. Consume any analgesic (pain-relieving) or anti-inflammatory drug(s), prescription or non-prescription, chronically 3. A history of neuromuscular problems or muscle-wasting diseases 4. Any acute chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin dependent diabetes or other metabolic disorders- all ascertained through medical screening questionnaires 5. Chronic consumption of statins (particularly simvastatin/Zocor and atorvastatin/Lipitor) used to lower cholesterol 6. Be on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription-strength acne medications) 7. Have allergies or are not willing to consume eggs 8. Consume a vegetarian diet 9. Had significant weight gain or loss in the past 6 months 10. Have injuries preventing the safe completion of the exercise

Locations (1)

Ivor Wynne Centre

Hamilton, Ontario, Canada

Outcomes

Primary Outcomes

Dietary protein intake.

Dietary protein intake (specifically meal-to-meal distribution) will be measured in all participants using a 3-day food log.