Safety and Immunogenicity of a Sabin Inactivated Poliovirus Vaccine (Phase Ib)

Inclusion Criteria: * Healthy volunteer aged 18\~45 years with/without prior vaccination of poliovirus and without any contraindication for vaccination; * Healthy volunteer aged 4 years with/without prior vaccination of poliovirus but without booster vaccination and any contraindication for vaccination; * Healthy volunteer aged 2 months (60\~90 days) without prior vaccination of poliovirus and any contraindication for vaccination; * Guardians of the participants should be capable of understanding the written consent form, and such form should be signed prior to enrolment; * Complying with the requirement of the study protocol; * Axillary temperature ≤ 37.0 °C; Exclusion Criteria: * Women aged 18\~45 years with positive urine pregnancy test, pregnant or lactating women, or women with pregnancy plans within 3 months; * Preterm or low birth weight infants; * Congenital malformation, developmental disorders, genetic defects, or severe malnutrition; * History of polio; * Severe nervous system disease (epilepsy, seizures or convulsions) or mental illness; * History of allergy to any vaccine, or any ingredient of the vaccine, or serious adverse reaction(s) to vaccination, such as urticaria, dyspnea, angioneurotic edema, abdominal pain, etc; * Autoimmune disease or immunodeficiency/immunosuppressive; * Bleeding disorder diagnosed by a doctor (e.g., coagulation factor deficiency, coagulation disorder, or platelet disorder), or significant bruising or coagulopathy; * Serious chronic diseases, respiratory diseases, cardiovascular diseases, liver or kidney diseases or skin diseases; * Mother of the participant has HIV infection; * Acute illness or acute exacerbation of chronic disease within the past 7 days; * Had a high fever within the past 3 days (axillary temperature ≥ 38.0°C); * Receipt of any subunit or inactivated vaccine within the past 7 day; * Receipt of any live attenuated vaccine within the past 14 days; * Receipt of any blood product within the past 3 months; * Any other factor that, in the judgment of the investigator, suggesting the volunteer is unsuitable for this study;