Stool samples will be collected before and during the HyGIeaCare procedure and the samples will be sent for microbiome evaluation.
Patients will have the HyGIeaCare procedure as originally prescribed by their physician. Before and during the procedure stool samples will be collected and sent to a lab for microbiome evaluation. It is anticipated that stool samples collected from the HyGIeaCare prep will provide more microbiological and biochemical information on the gut interior than using traditional stool samples.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
14
Each patient will have up to 5 stool specimens for evaluation by a lab for microbial contents.
HyGIeaCare Center
Norfolk, Virginia, United States
Microbial classification
The number of genes present will be counted
Time frame: 6 months
Diversity between stool and colon effluent samples
Alpha diversity by Shannon diversity index, presence and number of taxa to be documented
Time frame: 6 months
Inner diversity of samples
ANOVA test will be used to acknowledge differences between samples, presence and number of taxa to be documented
Time frame: 6 months
Contribution of the variables to samples' diversity
Principal component analysis (PCoA) will be used to mark significant differences between the samples, taxa will be identified by presence, percentage of sample will be documented
Time frame: 6 months
Functional genes analysis
The presence of genes known to represent biochemical functions will be counted and documented
Time frame: 6 months
Biosynthetic gene clusters
Groups of genes with known biosynthetic functions and found to be clustered will be counted and documented together in the different samples
Time frame: 6 months
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