Analysis of Driver Gene Mutation in Early Stage Non-small Cell Lung Cancer

Zhejiang Cancer Hospital237 enrolled

Overview

Analysis of driver gene variation in early stage non-small cell lung cancer

Fluorescence quantitative polymerase chain reaction (PCR) was used to detect the variation of driver gene in regional lymph nodes of early stage non-small cell lung cancer (NSCLC), and to analyze the relationship between the variation and disease recurrence and survival prognosis. evaluate the effect of the variation of driving gene in lymph nodes of early stage NSCLC on prognosis, identify the high-risk factors that promote the recurrence and metastasis of early stage tumor. so as to improve the diagnosis and treatment path of lung cancer, provide important pathological basis for the clinical diagnosis and treatment of early stage non-small cell lung cancer, enable patients to receive more accurate treatment, and improve their survival prognosis.

Study Type

OBSERVATIONAL

Enrollment

237

Conditions

Non-small Cell Lung Cancer

Interventions

nonInterventionOTHER

nonIntervention

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Female or male, 18 years of age or older 2. Histologically or cytologically proven diagnosis of early stage NSCLC 3. The lesion was completely resected by radical surgery 4. Able to get tumor tissue sample 5. Complete information of clinicopathological , survival, recurrence and metastasis can be obtained through follow-up Exclusion Criteria: 1. Combine with other tumor type 2. The investigator judges the situation that may affect the clinical search process and results

Outcomes

Primary Outcomes

Driver gene mutation frequency of early stage NSCLC

Observe the driver gene mutation frequency in regional lymph nodes of early stage non-small cell lung cancer

Time frame: 2019

Correlation of Clinicopathological characteristics and driver gene mutation in regional lymph nodes of early stage NSCLC

Analyze the correlation between driver gene mutation and clinicopathological features in regional lymph nodes of early stage NSCLC

Time frame: 2019

Correlation between driver gene mutation and survival prognosis in regional lymph nodes of early stage NSCLC

Observe the correlation between driver gene mutation and survival prognosis in regional lymph nodes of early stage NSCLC

Time frame: 2019

Data from ClinicalTrials.gov

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