The aim of this project is to investigate the association of glutathione peroxidase (GPx) and severe aortic stenosis (AS), as well as the impact of transcatheter aortic valve replacement (TAVR) on GPx activity post-procedure. The burden of oxidative stress will be determined by the measurement of GPx, superoxide dismutase (SOD) and lipoprotein A (Lp(a)). We hypothesize GPx activity is reduced in participants with severe AS vs control groups and GPx activity is to increase after TAVR is performed.
Study Type
OBSERVATIONAL
Routine blood draw to measure levels of blood markers.
Routine blood draw to measure levels of blood markers.
Routine blood draw to measure levels of blood markers.
University of Florida
Jacksonville, Florida, United States
Level of GPx in blood samples
Glutathione peroxidase activity levels measured from whole blood in U/L units in participants with severe aortic stenosis after transcatheter valve replacement compared with the matched population
Time frame: Baseline up to 6 months
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