Oral and Systemic aMMP-8 in Periodontal Disease

Aydin Adnan Menderes University83 enrolled

Overview

Periodontal disease is an inflammatory process that can result in tooth loss and also is considered a modifying factor for systemic health. Matrix metalloproteinase (MMP)-8 is the major collagenase of periodontal tissue breakdown. The aim of the present study is to analyze active (aMMP-8) levels in gingival crevicular fluid (GCF), saliva and serum in the context of new criteria of gingivitis and stage 3 grade C periodontitis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Periodontal Diseases Periodontal Inflammation

Interventions

Biochemical analysisOTHER

aMMP-8 is measured by immunofluorometric assay (IFMA).

Eligibility

Sex: ALLMin age: 25 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * systemically healthy and non-smoker individuals aged 25 to 50 years * having ≥20 teeth present (except third molars) * individuals with periodontally healthy, gingivitis and stage 3 periodontitis diagnoses Exclusion Criteria: * having any systemic disease * smoking * pregnancy or lactation * using antibiotic or any anti-inflammatory drug or any periodontal treatment within the past 6 months.

Locations (1)

Aydin Adnan Menderes University

Aydin, Turkey (Türkiye)

Outcomes

Primary Outcomes

Oral (GCF and saliva) and serum levels of aMMP-8 in periodontitis and gingivitis

aMMP-8 levels

Time frame: through study completion, an average of 4 months

Data from ClinicalTrials.gov

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