Comparing the Effect of Sitagliptin/Metformin and Metformin in PCOS Patients

Shahid Beheshti University of Medical Sciences80 enrolled

Overview

Investigators will evaluate and compare the efficacy of Sitagliptin/Metformin to metformin and sitagliptin on gdf9 and bmp15 gene expression on PCOS patients undergoing intracytoplasmic sperm injection(ICSI).

This study was conducted in Infertility clinic of Mahdiyeh Educational Hospital, Tehran. Patients in the four groups receive the drug 2 months before the start of the ovulation cycle, and treatment will continue until the day of the oocyte aspiration. The drug provide by midwife to patients and both patient and physician blind to the treatment regimen. The participants randomly divide into four groups.The ovulation induction stimulate with GnRh antagonist.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Polycystic Ovary Syndrome Infertility ART

Interventions

placeboDRUG

Oral rehydration solution

metforminDRUG

metformin tablet

SitagliptinDRUG

Sitagliptin tablet

Sitagliptin/metformin

Eligibility

Sex: FEMALEMin age: 25 YearsMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * subject has clinical or biochemical hyperandrogenic symptoms * subject has oligo/amenorrhea cycles Exclusion Criteria: * Hypersensitivity to metformin * Hypersensitivity to sitagliptin presence of infertility factors other than anovulation, * male infertility * pelvic organic pathologies * congenital adrenal hyperplasia * thyroid dysfunction * Cushing's syndrome * hyper prolactinemia * androgen secreting neoplasia * diabetes mellitus * consumption of medications affecting carbohydrate metabolism * consumption hormonal analogues other than progesterone 2 months prior to enrolment in the study * severe hepatic * pancreatitis * kidney diseases * gallbladder diseases

Locations (1)

Mahdiyeh educational hospital

Tehran, Iran

RECRUITING