Dexmedetomidine may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of dexmedetomidine. The investigators have therefore performed the present study to measure the effect of dexmedetomidine on the coagulation pathway according to the drug concentration level using a rotational thromboelastometry test.
Study Type
OBSERVATIONAL
Enrollment
11
Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0 ul) using dexmedetomidine
Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0.25 ul) using dexmedetomidine
Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0.5 ul) using dexmedetomidine
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
FIBTEM
Fibrinolytic pathway values of rotational thromboelastometry analysis/ FIBTEM is not an acronym.
Time frame: During the rotational thromboelastometry analysis/ an average of 1 hour
INTEM
Intrinsic pathway values of rotational thromboelastometry analysis/ INTEM is not an acronym.
Time frame: During the rotational thromboelastometry analysis/ an average of 1 hour
EXTEM
Extrinsic pathway values of rotational thromboelastometry analysis/ EXTEM is not an acronym.
Time frame: During the rotational thromboelastometry analysis/ an average of 1 hour
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0.75 ul) using dexmedetomidine