Serious Pneumonia and Critical Pneumonia caused by the 2019-nCOV infection greatly threats patients' life, UC-MSCs treatment has been proved to play a role in curing multiple diseases. And this study is conducted to find out whether or not it will function in 2019-nCOV infection Pneumonia.
Serious Pneumonia and Critical Pneumonia caused by the 2019-nCOV infection greatly threats patients' life, UC-MSCs treatment has been proved to play a role in curing multiple diseases. And this study is conducted to find out whether or not it will function in 2019-nCOV infection Pneumonia. And we are going to get the permission of the enrolled patients. Besides the present clinical treatment, UC-MSCs treatment will be applied to those fulfilling the enrollment. After a period of UC-MSCs treatment, the analysis of UC-MSCs treatment will be completed from related aspects.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
16
After enrollment, each subject will receive UC-MSCs infusion intravenously on day 1, day 3, day 5, and day 7.
Zhongnan Hospital of Wuhan University
Wuhan, Hubei, China
RECRUITINGOxygenation index
partial arterial oxygen pressure (PaO2) / oxygen concentration (FiO2)
Time frame: on the day 14 after enrollment
28 day mortality
whether the patient survives
Time frame: on the day 28 after enrollment
Hospital stay
days of the patients in hospital
Time frame: up to 6 months
2019-nCoV antibody test
whether or not the 2019-nCoV antibody is positive
Time frame: on the day 7,14,28 after enrollment
2019-nCoV nucleic acid test
whether or not the 2019-nCoV nucleic acid test is positive
Time frame: on the day 7,14,28 after enrollment
Improvement of lung imaging examinations
whether lung imaging examinations show the improvement of the pneumonia
Time frame: on the day 7,14,28 after enrollment
White blood cell count
counts of white blood cell in a litre of blood
Time frame: on the day 7,14,28 after enrollment
Lymphocyte count
counts of lymphocyte in a litre (L) of blood
Time frame: on the day 7,14,28 after enrollment
Procalcitonin
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procalcitonin in microgram(ug)/L
Time frame: on the day 7,14,28 after enrollment
interleukin(IL)-2
IL-2 in picogram(pg)/millilitre(mL)
Time frame: on the day 7,14,28 after enrollment
IL-4
IL-4 in pg/mL
Time frame: on the day 7,14,28 after enrollment
IL-6
IL-6 in pg/mL
Time frame: on the day 7,14,28 after enrollment
IL-10
IL-10 in pg/mL
Time frame: on the day 7,14,28 after enrollment
tumor necrosis factor(TNF)-α
TNF-α in nanogram(ng)/L
Time frame: on the day 7,14,28 after enrollment
γ-interferon(IFN)
γ-IFN in a thousand unit (KU)/L
Time frame: on the day 7,14,28 after enrollment
C-reactive protein(CRP)
CRP in microgram(μg)/L
Time frame: on the day 7,14,28 after enrollment
CD4+ T-Lymphocytopenia
counts of CD4+ T-Lymphocytopenia in litre
Time frame: on the day 7,14,28 after enrollment
CD8+ T-Lymphocytopenia
counts of CD8+ T-Lymphocytopenia in a litre
Time frame: on the day 7,14,28 after enrollment
natural killer cell(NK)
counts of NK in a litre
Time frame: on the day 7,14,28 after enrollment