Impact of Cannabis on Pain and Inflammation Among Patients With Rheumatoid or Psoriatic Arthritis

Inclusion Criteria: 1. current RA or PA diagnosis with active arthritis not adequately controlled by standard medication 2. if taking prescribed steroid, non-steroidal anti-inflammatory (NSAID), and/or disease-modifying anti-rheumatic drug (DMARDS; e.g., tumor necrosis factor inhibitors), must be stable use for at least 1 month prior to enrollment (all must be maintained throughout the study) 3. English-speaking or Spanish-speaking 4. negative urine toxicology screen 5. negative pregnancy test 6. not nursing 7. use of highly effective birth control during the study for both males and females 8. prior history of vaping or smoking cannabis Exclusion Criteria: 9. greater than zero breath alcohol concentration 10. presence of psychosis, panic disorder, or suicidal ideation or intent 11. self-report of serious adverse reaction to cannabis in the past year 12. smoking more than 20 tobacco cigarettes per day 13. body mass index below 18.0 or above 33.0 kg/m2 range confirmed during medical exam 14. all current asthma conditions (i.e., active symptomatic asthma within the last week) or current or past history of asthma triggered by smoking or vaping 15. current diagnosis of dementia or Parkinson's disease 16. below cut-off on mental status exam 17. current diagnosis of moderate to severe traumatic brain injury 18. current diagnosis of epilepsy 19. individuals who are immunocompromised (i.e., post-organ transplant, those with an immune deficiency disorder such as HIV, individuals taking immunosuppressant steroids such as continuous prednisone use, and those with lupus) 20. past kidney disease (e.g., glomerular nephritis, polycystic kidney disease) and/or presence of elevated creatinine 21. cardiac disease confirmed via clinically significant abnormal findings on an EKG (e.g., arrhythmia, conduction abnormalities, ischemia, or evidence of past myocardial infarction), as well as diagnoses of congestive heart failure or cardiomyopathy 22. abnormal vital signs 23. taking any exclusionary medications 24. presence of any severe cardiovascular, renal, or hepatic disorder 25. below 18 or above 65 years of age 26. use of cannabis in the past 1 month before commencement of study participation and throughout the study as confirmed via urine toxicology screening aa) below minimum self-reported pain level on a visual analog scale (VAS) pre-study enrollment via telephone and at baseline due to potential variability in pain level