Evaluation of Adipose Derived Stem Cells Exo.in Treatment of Periodontitis

Early Phase 1UnknownNCT04270006

Beni-Suef University10 enrolled

Overview

The adipose stem cells exosomes will be extracted from adipose stem cells isolated autogenously from the patient to be injected locally into the periodontal pockets in order to evaluate their regenerative effect.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Periodontitis

Interventions

adipose derived stem cells exosomesBIOLOGICAL

they are small extracellular vesicles

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Advanced periodontitis (Stage III or IV) * Healthy patients. Exclusion Criteria: * Smokers, Diabetic, Pregnant ladies, Under corticosteroids or contraceptive treatment,poor oral hygiene.

Locations (2)

Beni-Suef University

Banī Suwayf, Egypt

RECRUITING

Cairo University

Cairo, Egypt

RECRUITING

Outcomes

Primary Outcomes

change in gingival inflammation

Gingival index (GI)

Time frame: 0, 3 and 6 months

change in pocket depth

Probing depth (PD)

Time frame: 0, 3 and 6 months

change in attachment level

Clinical attachment level (CAL)

Time frame: 0, 3 and 6 months

change in Bone level

Cone beam C.T (CBCT)

Time frame: 0 and 6 months

Central Contacts

Ebtehal Mohammed, Ph.D

CONTACT

01224336896 ebtehalmaawad@dent.bsu.edu.eg,

Noha Saleh, Ph.D

CONTACT

noha.saleh@dentistry.cu.edu.eg

Data from ClinicalTrials.gov

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