The investigators proposed that pain, agitation, delirium and sleep deprivation protocol (PADS) will help improve the patients' outcomes (shortening ICU length of stay, improving ventilator free days, increasing delirium free days) in critically ill patients, a university hospital, Thailand.
Pain is frequently reported in patients admitted to an ICU, with an incidence of up to 50% in medical patients during admission, and increasing up to 80% during standard care procedures. Agitation was also reported in 52% of the patients, typically within 4-9 days after admission. However, there were studies reporting inadequate pain, agitation and delirium assessment and management in real-world clinical practice. The clinical practice guideline for the management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU was recently published in 2018 and emphasized routinely monitoring pain, agitation and delirium during ICU admissions. Also, appropriate management of pain and agitation in critically ill patients resulted in reduction in ICU length of stay, hospital length of stay, delirium and mortality. Therefore, structural pain, agitation/sedation, delirium assessment and treatment in the ICUs, Thailand might be necessary. Since pain, agitation/sedation and delirium protocol has not yet been initiated in ICUs, Thailand, this study is designed as a before-after study in order to assess outcomes by comparing between before and after protocol initiation. The objectives of the study were to document the impact of pain, agitation/sedation, delirium protocol on clinical outcomes of ICU patients admitted to ICUs at Ramathibodi Hospital, a university hospital, Thailand
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
509
Assessment and management per PADS protocol
Ramathibodi Hospital, Mahidol University
Bangkok, Thailand
ICU free days
Days alive and not stay in ICU
Time frame: During ICU stay or death or a maximum of 28 days
Mechanical ventilator free days
Day alive and free of mechanical ventilator
Time frame: During ICU stay or death or a maximum of 28 days
Delirium free days
Day alive and free of delirium
Time frame: During ICU stay or death or a maximum of 28 days
Frequency of pain, agitation/sedation, delirium, sleep deprivation assessement
Times per patient-days of evaluations during ICU stay
Time frame: During ICU stay or death or a maximum of 28 days
Incidence of in-target pain, agitation/sedation, delirium
Times per patient-days of in-target pain, agitation/sedation, delirium during ICU stay
Time frame: During ICU stay or death or a maximum of 28 days
Compliance to PADS protocol
Times per patient-days of PADS protocol use by healthcare providers during ICU stay
Time frame: During ICU stay or death or a maximum of 28 days
All-cause hospital mortality
Rates of all-cause mortality during hospital stay
Time frame: During hospital stay or death or a maximum of 90 days
Antipsychotics use
Type and dose of antipsychotics during ICU stay
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Time frame: During ICU stay or death or a maximum of 28 days
Non-benzodiazepines use
Type and dose of non-benzodiazepines during ICU stay
Time frame: During ICU stay or death or a maximum of 28 days
Benzodiazepines use
Type and dose of non-benzodiazepines during ICU stay
Time frame: During ICU stay or death or a maximum of 28 days