A First-in-Human Study of RPT193 in Healthy Volunteers and Patients With Atopic Dermatitis

Selected Inclusion Criteria: Parts A \& B (COMPLETED ENROLLMENT): * Healthy male or female * 18-55 years of age, inclusive * At least 50 kg in weight * BMI: 18.0-30.0 kg/m2, inclusive Part C (COMPLETED ENROLLMENT): * Male or female with atopic dermatitis * 18-65 years of age, inclusive * BMI between 18.0 (inclusive) and \<40.0 kg/m2 * Body surface area (BSA) with AD involvement ≥10% * Eczema Area and Severity Index (EASI) score ≥12 * Validated Investigator's Global Assessment (vIGA) ≥3 * History of inadequate response to treatment with topical medications, such as corticosteroids or calcineurin inhibitors, or patients for whom topical treatments are otherwise medically inadvisable Selected Exclusion Criteria: Parts A \& B (COMPLETED ENROLLMENT): * Use of tobacco products within 60 days prior to drug administration * History of alcohol abuse or drug addiction * Positive drug and alcohol screen * Participation in a drug study within 60 days prior to drug administration * Donation or loss of more than 100 mL of blood within 60 days prior to drug administration. * Donation or loss of more than 1.5 liters of blood (for male subjects) / more than 1.0 liters of blood (for female subjects) in the 10 months prior to drug administration. Part C (COMPLETED ENROLLMENT): * Any serious and/or uncontrolled medical condition * History of alcohol abuse or drug addiction * Positive drug and alcohol screen