Analgesic Effects of Cannabidiol for Simple Tooth Extractions in Dental Patients

Phase 3CompletedNCT04271917

University of Tennessee68 enrolled

Overview

The purpose of this study is to evaluate the analgesic effects of cannabidiol for patients who have undergone simple tooth extraction. Participants will be randomized to one of four arms: treatment-as-usual (TAU), cannabidiol 17mg/mL, cannabidiol 37mg/mL, or placebo.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Pain, Acute

Interventions

cannabidiolDRUG

Use of cannabidiol as an alternative to standard of care treatment of acute pain.

placeboDRUG

Inactive placebo oil to imitate CBD oil

acetaminophen 500mg and ibuprofen 200mg comboDRUG

standard of care

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Presenting for an operatory appointment at University of Tennessee Health Science Center College of Dentistry Oral and Maxillofacial Surgery Department * Operation must be a simple tooth extraction which does not result in an opioid prescription * 18 years of age or older * Have regular and direct access to a device that can send and receive texts and willing to accept any associated charges for 24 text messages Exclusion Criteria: * Contraindication to ibuprofen * Contraindication to acetaminophen * Contraindication to cannabidiol or hemp oil * Contraindication to peppermint oil * Contraindication to almond or other tree nuts * Currently taking a form of cannabidiol and unwilling to stop use for one week post surgery

Locations (1)

University of Tennessee Health Science Center

Memphis, Tennessee, United States

Outcomes

Primary Outcomes

Worst pain following surgery using Wong Baker Faces pain scale

Self-report of participant's worst pain after surgery

Time frame: 1-week post-op

Amount of medication used

Self-report of total amount of pain medication used from participant diary

Time frame: 1-week post-op

Pain levels following surgery using Wong Baker Faces pain scale

Self-reported pain recorded every 2 hours between 7am-9pm by automated SMS messaging.

Time frame: First 72 hours post-op

Data from ClinicalTrials.gov

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