The purpose of this study is to validate the interest of broadband spectroscopy analysis (femto/attosecond by infrared laser) on liquid biopsies in breast cancer screening.
Each patient will have one or more liquid biopsy during the follow-up according to the cohort and have a mammogram at the same time. Biopsies will be analysed by broadband spectroscopy in order to compare the results to mammogram result.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
1,100
Blood sample collection during follow-up of the three cohorts of patients
Centre Jean PERRIN
Clermont-Ferrand, Puy de Dome, France
La Chataigneraie (Selimed 63)
Beaumont, Puy de Dôme, France
Pôle Santé République
Clermont-Ferrand, Puy de Dôme, France
Institut de Cancérologie de l'Ouest
Angers, France
Validation of the value of molecular profiling analysis in broadband laser spectroscopy on liquid biopsies for breast cancer screening
To validate the value of molecular profiling analysis in broadband laser spectroscopy on liquid biopsies for invasive breast cancer screening by comparing a cohort of patients with localized invasive breast cancer (Stage I/II) to a cohort of women without invasive breast cancer from organized or individual age-matched screening.
Time frame: Comparison between the different cohorts at (T0 : inclusion) and the others visits (T1:+1year; T2: +2years; T3 : +3years; T4:+4years; T5: 5years)
Correlating the results of high-speed laser spectroscopy analysis on liquid biopsies with mammography data (ACR 0-5)
The results of high-speed laser spectroscopy analysis on liquid biopsies will be correlated with mammography data
Time frame: T0: inclusion; T1:+1year; T2: +2years; T3 : +3years; T4:+4years; T5: 5years
Estimate detection rate of both breast cancer screening methods (spectroscopy/mammography) for control cohort
Estimate the rate of detection of invasive breast cancer occurring within 5 years of examination in the control group according to the reference method (mammography) and the innovative method ("n-variable molecular profiles") from the baseline analysis performed at Max Planck Institute and algorithmic analysis
Time frame: T0 : inclusion; T2 : +2 years; T4: +4years
To study the role of confounding factors in the structure of molecular profiles derived from broadband laser spectroscopy
To study the confounding role of hormonal status and concomitant inflammatory states in the structure of molecular profiles derived from broadband laser spectroscopy
Time frame: T0: inclusion; T1:+1year; T2: +2years; T3 : +3years; T4:+4years; T5: 5years
Comparison of BRCA1/2 patients molecular profiles with control and patient cohorts derived from broadband laser spectroscopy
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Centre Eugène MARQUIS
Rennes, France
Institut de Cancérologie de l'Ouest
Saint-Herblain, France
Hôpital La Pitié Salpêtrière
Paris, Île-de-France Region, France
Hôpital Saint-Louis
Paris, Île-de-France Region, France
Hôpital Tenon
Paris, Île-de-France Region, France
To study the molecular profiles derived from broadband laser spectroscopy on liquid biopsies in a cohort of high-risk women (BRCA1/2) not carrying invasive breast cancer, and to compare their positioning in relation to the 2 main cohorts of the study (patients carrying invasive breast cancer without mutation and controls without invasive breast cancer).
Time frame: T0: inclusion; T1:+1year; T2: +2years; T3 : +3years; T4:+4years; T5: 5years