Chagas disease is caused by parasite Trypanosoma Cruzi. In Argentina, there is an estimated of 1.600.000 infected people. Due to migration phenomenon, most cases live in urban areas without vectorial transmission. Pharmacological treatment is given to prevent development of cardiac and gastrointestinal sequelae. There are two available drugs for this disease; Nifurtimox and Benznidazole. They both has proven efficacy for acute face treatment, with different security profiles. There are not enough adequate studies comparing both drugs made in a large number of subjects. Investigators will study 900 patients treated with both drugs and compare security and efficacy in a retrospective cohort.
Study Type
OBSERVATIONAL
Enrollment
900
Clinical manifestations in patients treated with Nifurtimox and Benznidazole
Serologic response in patients treated with Nifurtimox and Benznidazole
Direct method tests in patients treated with Nifurtimox and Benznidazole
Adverse events in patients treated with Nifurtimox and Benznidazole
Parasitology and Chagas Service, Buenos Aires Children´s Hospital Ricardo Gutierrez
Buenos Aires, Argentina
Nifurtimox versus Benznidazole serologic, parasitemia and clinical response for treatment in patients
To compare Nifurtimox versus Benznidazole treatment efficacy, by measuring serologic response, parasitemia and clinical manifestations in infected patients
Time frame: Patients treated from 1984 to 2017
Nifurtimox versus Benznidazole security and tolerance
To compare Nifurtimox versus Benznidazole security profiles, by measuring adverse events in infected patients and comparing both groups (number of adverse reactions, type and severity of reactions)
Time frame: Patients treated from 1984 to 2017
To compare Chagas disease characteristics associated with treatment
To describe source of infection, age of acquisition of parasite, diagnosis time frame and clinical manifestations that may be associated with treatment response and compare both groups
Time frame: Patients treated from 1984 to 2017
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