The purpose of this study is to observe the relationship between the level of lipid peroxidation products in serum of patients with traumatic brain injury and secondary coagulation disorders.
Uncontrolled hemorrhage after trauma is the leading cause of death. The mechanism of secondary coagulation dysfunction after trauma is special and complex, which has not been fully explained, leading to limited treatment and prevention methods. Coagulation disorders caused by traumatic brain injury is a systemic manifestation of local injury, which can activate platelets and promote platelet aggregation, activate thrombin, and promote the production of fibrin, leading to the formation of thrombosis. However, in non-injured areas, pro-coagulant molecules from damaged brain tissue reach the body through the broken blood-brain barrier, and also activate platelets and thrombin, promoting the formation of blood clots. Lipid peroxidation products are closely related to the occurrence of coagulation dysfunction. The effects lipid peroxidation products on platelets, thrombin and anticoagulant pathways may be a novel mechanism of secondary coagulation dysfunction in traumatic brain injury.
Study Type
OBSERVATIONAL
Enrollment
100
Tandu Hospital, Fourth Military Medical University
Xi'an, Shaanxi, China
RECRUITINGThe level of lipid peroxidation products in subjects' serum
the level of high and low
Time frame: within 24 hours of trauma
Coagulation Disorders
aPTT\>40s or INR\>1.4 or \<100 platelets per L
Time frame: within 24 hours of trauma
The 24-hour and 3-month Glasgow outcome score (GOS)
Time frame: from onset to three months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.