Analyze the dynamics of incorporation of 5-fluorouracil into cancer cell ribosomes from liver metastases of patient with metastatic colon cancer.
This is a monocentric, prospective, non-interventional cohort study in adult patients with metastatic colon cancer with hepatics metastasis. Tumour samples collected for this study include: * A fragment of the previously operated primary tumor: FFIP block and/or archived frozen tumor if available. * A fragment of the liver metastasis(s) performed as part of standard metastasis surgery, this fragment will include a tumor area and a healthy area within the margin of excision. These samples collected in a fresh state will be analyzed immediately.
Study Type
OBSERVATIONAL
Collection of tumour samples from samples collected as part of standard patient management. Diagnostic pathological analysis will be a priority. These samples will be taken by experienced staff during the hospital visit scheduled as part of standard care.
Centre Léon Bérard
Lyon, France
5-FU in ribosome
Rate of incorporation of 5-fluorouracil into ribosomes of tumor tissues and adjacent healthy tissues before surgery and after surgery.
Time frame: Up to 24 months
Methylation profile of ribosomal RNAs
Analyze on a large scale the alterations of the 2'-O-methylation profile of ribosomal RNAs before surgery and after surgery
Time frame: Up to 24 months
Transcriptomic and proteomic profile
Define a transcriptomic and proteomic profile of the collected samples before surgery and after surgery.
Time frame: Up to 24 months
Specific molecular signature
Combination of the number of 5-fluorouracil molecules incorporated per rRNA molecule, the methylation profile and the transcriptomic profile before surgery and after surgery.
Time frame: Up to 24 months
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