Impact of Iron Stores on Wound Healing in Plastic Surgery

Assistance Publique - Hôpitaux de Paris400 enrolled

Overview

In breast reduction surgery, delayed wound healing may increase surgical site infections, cutaneous necrosis and may be related to psychological harm.Some risk factors have been identified : smoking, diabetes, overweight. A normal healing involve cellular and biochemical reactions in which iron plays an important role such as cellular respiration, redox reactions and regulation of genes involved in the cell cycle. This trial will study the relationship between iron stores and postoperative wound healing after bilateral breast reduction surgery in patients without preoperative anaemia.The primary outcome of this trial is the comparison of wound healing at post operative day 15, between patients with and without iron deficiency.

Study Type

OBSERVATIONAL

Enrollment

400

Conditions

Healing Wound Iron-deficiency Surgical Wound

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age \>18 years * female * scheduled bilateral breast reduction surgery * biological exams with ferritin and transferrin saturation coefficient taken the day before surgery * No anemia : haemoglobin \>=12g/dL (preoperative biological assessment ) * if genetic disease of haemoglobin, haemoglobin between 10 and 12g/dL and no Anaemia by iron deficiency * absence of clinical inflammatory syndrome (no clinical signs of infection or no fever) * non-opposition of the patient to participate Exclusion Criteria: * Anaemia by iron deficiency

Outcomes

Primary Outcomes

Proportion of good breast tissue healing on each breast

Good healing is defined as a score of 0, 1 or 2 on a 16 points-specifc scale. The scale evaluate proportion of disunity for periareolar vertical and horizontal incisions