OCT- Versus Angiography-guided Paclitaxel Drug-Coated Balloon Angioplasty in De Novo Coronary Artery

Inclusion Criteria: 1. 18 to 85 years old 2. Patients have ischemic symptoms or evidence of myocardial ischemia (inducible or spontaneous) in the presence of a stenosis of at least 50% in a native coronary artery, including stable angina, unstable angina, or silent ischemia. 3. Reference vessel diameter \>2.5 mm, and \<4.0 mm. 4. Lesion length of \<22 mm 5. Written informed consent Exclusion Criteria: 1. Myocardial infarction within 4 weeks, including ST-elevation myocardial infarction and non-ST-elevation myocardial infarction 2. Cardiogenic shock (systolic arterial pressure \<90mmHg), congestive heart failure (NYHA or Killip≥3) 3. Chronic kidney disease (eGFR \<30 ml/min) 4. Lesion length \>22 mm, or vessel diameters of \<2.5 mm or \>4.0 mm 5. Stents covering a major side branch (\>2 mm) 6. Left main lesion 7. Graft lesion 8. Aortic-coronary ostial lesion 9. In-stent restenotic lesion 10. Chronic total occlusion 11. Severe calcified lesions. 12. Visible angiographic thrombus 13. Severe comorbidities: eg. malignancy (life expectancy \<2 years)