Alzheimer's disease (AD) is a prevalent, long-term progressive degenerative disorder with great social impact. It is currently thought that, in addition to neurodegeneration, vascular changes also play a role in the pathophysiology of the disease. Meantime, EEG resting state has also demonstrated significant change in patients with AD in neuroscience research area. Thus, the combination of these sensitive biomarkers would lead to a potential new biomarker for detection of AD, which has higher specificity and sensitivity.
Study Type
OBSERVATIONAL
Enrollment
60
No intervention
Zhongshan Ophthalmic Center
Guangzhou, Guangdong, China
OCT retinal and choroidal thickness
retinal structural anatomy
Time frame: 2 days
Retinal Photography vascular caliber
use Retinal Photography to detect vascular caliber
Time frame: 2 days
functional connection strength in the brain network
record resting-state EEG, use graph theory to calculate the functional connection strength
Time frame: 7 days
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