The Effect of Losartan on the Recoverability of Renal Function in Anuric and Oliguric Patients With Unilateral Obstructed Kidney

Mansoura University96 enrolled

Overview

Previous experimental studies concluded that angiotensin receptor blockers can ameliorate the harmful inflammatory and histological changes after relief of obstruction. Nevertheless, these witnessed effects have not been yet translated into the clinical practice.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Losartan Adverse Reaction Uropathy Uropathy Obstructive

Interventions

Cozaar (Losartan Potassium 25mg)DRUG

Cozaar (Losartan Potassium 25mg)

PlaceboDRUG

Placebo

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * anuric and oliguric patients * calculuar ureteral obstruction Exclusion Criteria: * anomalous kidney * bilateral obstructed kidney * history of recent use of angiotensin receptor blockers or angiotensin-converting enzyme inhibitors * ASA score of \>3

Locations (1)

Urology and nephrology center

Al Mansurah, Outside U.S./Canada, Egypt

Outcomes

Primary Outcomes

Renographic glomerular filtration rate of the affected kidney.

assessed by radioisotope renography using 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) in ml/min

Time frame: 3 months

Secondary Outcomes

Serum creatinine change

assessed by serum creatnine in mg/dl

Time frame: 3 months

Data from ClinicalTrials.gov

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