The incidence of laryngeal cancer accounts for about 1 \~ 5% of the total body tumors. For the surgical treatment of laryngeal cancer, the development trend of laryngocarcinoma treatment is to improve the local control rate, preserve the laryngeal function of patients as far as possible, and improve the life quality of patients. The efficacy, safety and feasibility of intraoperative radiotherapy (IORT) in head and neck cancer has been demonstrated in multiple institutional (3-5) studies to optimize local control. It is still unclear whether IORT can improve the local control and have efficacy, safety and feasibility in clinic. The purpose of this study was to observe the efficacy, safety and feasibility of IORT in local advanced laryngocarcinoma .
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
120
IORT in surgery of laryngocarcinoma
total laryngectomy or hemilaryngectomy
External radiotherapy
Tianjin First Central Hospital
Tianjin, Tianjin Municipality, China
RECRUITING2-year local recurrence rate
In this study, no matter whether distant metastases occurred, if there was the presence of any anastomotic or lateral node recurrences, it was defined as local recurrence. Criteria for local recurrence include (1) MRI results suggests local tumor recurrence, (2)Laryngoscopy indicates local tumor recurrence.
Time frame: 2 year
2-year disease free survival
Compare 2-year disease free survival in patients with local advanced laryngocarcinoma treated with or without IORT. Criteria for disease free survival means MRI and laryngoscopy (PET-CT if possible) indicate tumor free.
Time frame: 2 years
2-year overall survival
Compare 2-year overall survival in patients with local advanced laryngocarcinoma treated with or without IORT.
Time frame: 2 years
tissue necrosis
Compare the risk of tissue necrosis as determined visually by the Laryngoscope at 2 years after treatment in patients with local advanced laryngocarcinoma treated with or without IORT.
Time frame: 2 years
fibrosis
Compare the risk of fibrosis as determined visually by the Laryngoscope at 2 years after treatment in patients with local advanced laryngocarcinoma treated with or without IORT.
Time frame: 2 years
time of wound healing
Compare the time of wound healing after surgery in patients with local advanced laryngocarcinoma treated with or without IORT.
Time frame: up to 1 month
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