Effects of BKR-017 on Insulin Resistance in Type 2 Diabetes Patients

Inclusion Criteria: 1. Males and females between the ages of 18 and 70 years at the time of screening, inclusive 2. Diagnosed with T2D and under the care of a healthcare professional for its management 3. HbA1c 6.5-10.5%, inclusive 4. HOMA-IR 2.7 and above 5. Has given written informed consent to participate in this study 6. Willing to complete 28-day test period, including two overnight stays 7. Willing to maintain current diet and exercise routine and current prescription medications for the duration of the study Exclusion Criteria: 1. Type 1 diabetes 2. History of bariatric or intestinal surgery 3. Active gastrointestinal disease including but not limited to irritable bowel syndrome, inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis), diverticulitis, gastroparesis, or chronic/frequent diarrhea or chronic/frequent constipation 4. Active and clinically significant hepatic, pancreatic disease, or renal disease as determined by the investigator 5. History of significant heart disease, including congestive heart failure, prior MI, chronic atrial or ventricular fibrillation, coronary artery disease, cerebral vascular disease or other cardiovascular disease, that in the opinion of the investigator should exclude the subject from the study 6. Severely uncontrolled hypertension at screening defined as a systolic blood pressure \> 180 mmHg or a diastolic blood pressure \> 110 mmHg on the average of two seated measurements after being at rest for at least 5 minutes 7. Uncontrolled hyperthyroidism or hypothyroidism, or other significant thyroid disease 8. Active significant infection as determined by the investigator 9. Known allergy to butyrate or any of the components of the tablets 10. Participation in a clinical trial and/or treatment with an investigational drug during the 30 days before screening, or within 5 half-lives of receipt of an investigational drug or twice the duration of the biological effect of any investigational drug (whichever is longer) 11. Allergy or intolerance to Boost® High Protein drink 12. Pregnant, nursing, or trying to become pregnant 13. Presence of pitting edema on physical exam 14. High fiber diet 15. In the investigator's judgment, the subject is not suitable for the study for any other reason or cannot commit to the requirements of the study. 16. Subject is taking one or more of the excluded therapies. See list of excluded therapies in section 4.4.