Acute Intermittent Hypoxia in Persons With Multiple Sclerosis

Shirley Ryan AbilityLab10 enrolled

Overview

The overall objective of this project is to investigate the effectiveness of Acute Intermittent Hypoxia (AIH), to improve muscle strength and activity level in individuals with relapsing-remitting MS.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Multiple Sclerosis, Relapsing-Remitting

Interventions

Intermittent HypoxiaOTHER

1 minute of 9% oxygen in the inspired air, alternating with 1 minute of 21% oxygen; for a total of 15 iterations/episodes.

Sham HypoxiaOTHER

1 minute of 21% oxygen in the inspired air, alternating with 1 minute of 21% oxygen; for a total of 15 iterations/episodes.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Have relapsing-remitting MS * Volitional ankle plantar flexion strength in at least one leg * Are relapse free for 30 days * Patient-Determined Disease Steps scale score between 3 and 5 (3=gait disability to 5=late cane, need cane to walk 25 feet) Exclusion Criteria: * Currently taking antispasticity medications, * Have cardiovascular or respiratory/pulmonary disorders, metabolic dysfunction, or prior diagnoses of obstructive sleep apnea * Pregnant or nursing women (safety for developing fetus or infant is unknown) * Cognitive concerns (must be able to consent to study, follow steps)

Locations (1)

Shirley Ryan AbilityLab

Chicago, Illinois, United States

Outcomes

Primary Outcomes

Voluntary Ankle Strength

Maximum isometric ankle plantar-flexion and dorsi-flexion torque using a Biodex

Time frame: 60 minutes post-intervention

Secondary Outcomes

Electromyogram activity

Plantar-flexor and Dorsi-flexor electromyogram activity

Time frame: 60 minutes post-intervention

Symbol Digit Modalities Test

The symbol-digit modalities test (SDMT) is a symbol substitution neuropsychological test that examines a person's attention and speed of processing

Time frame: 60 minutes post-intervention

Data from ClinicalTrials.gov

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