The study focuses the mechanisms underlying the loss of intestinal homeostasis in celiac disease, refractory celiac disease and other immune diseases such as monogenic enteropathy, inflammatory bowel diseases or drug induced intestinal diseases. Mechanisms of transformation of lymphocytes leading to onset of lymphomatous complications of immune enteropathies will be investigated. Mechanisms of loss of hepatic lymphocytic homeostasis will also be assessed in liver associated diseases.
Study Type
OBSERVATIONAL
Enrollment
200
Targeted Next generation sequencing and whole exome sequencing Phenotyping of intestinal lymphocytes, single cell analyses, cytokines dosage...
Hôpital Henri Mondor
Créteil, France
NOT_YET_RECRUITINGHôpital Bicêtre
Le Kremlin-Bicêtre, France
NOT_YET_RECRUITINGHôpital Saint Louis
Paris, France
NOT_YET_RECRUITINGHôpital Cochin
Paris, France
RECRUITINGIntestinal Lymphocytes count
Lymphocytes isolation
Time frame: Baseline
DNA sequencing
Targeted Next Generation sequencing
Time frame: Baseline
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