The principal objective of this research is to determine whether symptoms, induced by confirmed experimental ischaemia, can help us predict which patients will respond to PCI.
Study Type
OBSERVATIONAL
Enrollment
80
Coronary artery stenting for stable angina
Essex Cardiothoracic Centre, Basildon and Thurrock University Hospitals NHS Trust
Basildon, Essex, United Kingdom
Imperial College Healthcare NHS Trust
London, United Kingdom
Placebo controlled similarity score during low pressure balloon occlusion of the coronary artery
Similarity Score (1-10) (Higher Score = Better Outcome)
Time frame: 30 Days
Change in angina symptom score
Fractional Change in Angina Frequency (0-1) (Lower Score = Better Outcome)
Time frame: 30 Days
Change in treadmill exercise time
Time frame: 30 Days
Change in treadmill time to chest pain
Time frame: 30 Days
Angina severity as assessed by Canadian Cardiovascular Society Class
Canadian Cardiovascular Society Class (0-IV) (Lower Score = Better Outcome)
Time frame: 30 Days
Physical limitation, angina stability, quality of life, angina frequency, freedom from angina as assessed with the Seattle Angina Questionnaire.
Seattle Angina Questionnaire, (Lower Score = Better Outcome)
Time frame: 30 Days
Quality of Life assessed with the EQ-5D-5L questionnaire
(Lower Score = Better Outcome)
Time frame: 30 Days
Change in dobutamine stress echocardiography score
(Lower Score = Better Outcome)
Time frame: 30 Days
Need for anti-anginal medication introduction and uptitration
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Time frame: 30 Days
Anxiety as assessed by the GAD-7 Score
Generalised anxiety and depression - 7 Score. (Lower Score = Better Outcome)
Time frame: 30 days
Depression as assessed by the PHQ-9 Score
Patient Health Questionnaire - 9. (Lower Score = Better Outcome)
Time frame: 30 days