Intestinal Microbiome Dynamics in Solid Organ and Stem Cell Transplant Recipients

Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology90 enrolled

Overview

This is a pilot study designed to investigate the alterations in the gut microbiome that occur during the course of kidney transplantation, liver transplantation, allogeneic hematopoietic stem cells and mesenchymal stem cells transplantation in association with the clinical outcomes.

This is a pilot study designed to investigate the dynamic changes in the intestinal microbiome that occur during the course of kidney transplantation, liver transplantation, allogeneic HSCs and mesenchymal stem cells transplantation. Four patient cohorts will be followed. Cohort A: patients receiving kidney transplantation. Cohort B: patients receiving hematopoietic stem cells transplantation. Cohort C: patients receiving mesenchymal stem cells transplantation. Cohort D: patients receiving liver transplantation. Included participants are defined as patients with at least three analyzable stool samples including a baseline sample before the transplantation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Transplantation Infection Kidney Transplant; Complications Stem Cell Transplant Complications Liver Transplant; Complications Microbial Colonization

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Participants enrolled into kidney transplantation or HSCs transplantation or MSCs transplantation or liver transplantation programs with fecal samples collected over the course of their initial transplant hospitalization. * Be willing and able to provide written informed consent for the study. Exclusion Criteria: * Patients were excluded from the study if their first sample was not collected prior to the start of transplantation procedure. * Samples were excluded from the analysis if they were not aliquoted and stored frozen within 24 hours of collection.

Outcomes

Primary Outcomes

Gut microbiome composition

Dynamics of gut microbiome composition over the course of transplantation (Shannon diversity index, Simpson index, abundance of main taxonomic phyla)

Time frame: 1 month post-transplant

Secondary Outcomes

Infectious complications after transplantation

Incidence of infectious complications

Time frame: 2 years post-transplant

Organ or tissue rejection

Incidence of organ or tissue rejection