Muscle atrophy and diaphragm dysfunction are common with prolonged mechanical ventilation (PMV). Electrical stimulation has been shown to be beneficial in severe chronic heart failure and chronic obstructive pulmonary disease. However, its effect on PMV is unclear. This study examined the effects of transcutaneous electrical diaphragmatic stimulation (TEDS) on respiratory muscle strength and weaning outcomes in patients with PMV.
Patients on ventilation for ≥21 days were randomly assigned to TEDS and control groups. The TEDS group received muscle electrical stimulation for 30 min/session/day throughout the intervention. Weaning parameters (tidal volume, respiratory rate, and rapid shallow breathing index) and respiratory muscle strength (Pimax, Pemax) were assessed. The hospitalization outcome, including weaning rate and length of stay, was followed up until discharge.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
59
The electrodes were placed on the parasternal region beside the xiphoid process; and the sixth and seventh intercostal spaces in line with the mid-axillary line. TEDS was set as biphasic waves, frequency of 30 Hz, pulse width of 400 μs, and rise time of 0.7s.
Chang Gung University
Taoyuan, Tao-Yuan, Taiwan
tidal volume
The tidal volume was measured by a spirometer
Time frame: 1st day of intervention
tidal volume
The tidal volume was measured by a spirometer
Time frame: through study completion,an average of 4 weeks
rapid shallow breathing index
respiratory rate/tidal volume
Time frame: 1st day of intervention
rapid shallow breathing index
respiratory rate/tidal volume
Time frame: through study completion,an average of 4 weeks
respiratory muscle strength (maximal inspiratory pressure)
pressure gauge
Time frame: the 1st day of intervention
respiratory muscle strength (maximal expiratory pressure)
pressure gauge
Time frame: the 1st day of intervention
respiratory muscle strength (maximal inspiratory pressure)
pressure gauge
Time frame: through study completion,an average of 4 weeks
respiratory muscle strength (maximal expiratory pressure)
pressure gauge
Time frame: through study completion,an average of 4 weeks
weaning rate
ventilator weaning results (weaning successful/failure)
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Time frame: through study completion,an average of 7 weeks
length of stay in respiratory care center
the total days of stay in respiratory care center
Time frame: through study completion,an average of 7 weeks