While advancements in cardiac magnetic resonance (CMR) have improved image quality, it is unclear how these improvements are connected to the clinical evaluation of individuals with cardiovascular disease. The aim of this large prospective registry revolves around 4 key principles: 1) utilize CMR to gain additional pathophysiologic insights into cardiovascular disease, 2) understand how CMR compares to alternative cardiovascular diagnostic modalities, 3) determine how CMR affects clinical management decisions, and 4) establish a link between CMR findings and long term prognosis in patients with known or suspected cardiovascular disease. The ultimate aim is to utilize CMR to improve patient outcomes. CMR techniques to be studies include function, fibrosis, and flow. Focus areas include valvular heart disease, ischemic heart disease, cardiomyopathies, and vascular disease.
Patient Population, Recruitment, and Consent: Patients presenting to the Houston Methodist DeBakey CMR Laboratory will be enrolled from April 2008 to April 2038. It is expected that up to 100,000 patients may be enrolled during this period. Subjects will be identified based on their referral to the Houston Methodist DeBakey CMR Laboratory for MRI studies during the proposed study period. After enrollment, a registered nurse or physician will perform a thorough structured patient interview and/or review of electronic health records to document baseline medical history including cardiac risk factors, symptoms, medication usage, and prior procedure history. A small blood sample will be drawn and stored for future biomarker and/or genetic testing analysis. Annual follow up for clinical status will be performed via review of electronic health records; structured telephone interviews with the patients, relatives, and/or their health care providers; and/or the social security death index database.
Study Type
OBSERVATIONAL
Enrollment
100,000
Patients will undergo various CMR techniques designed to assess cardiovascular structure and function, tissue characteristics, and flow.
Houston Methodist Hospital
Houston, Texas, United States
RECRUITINGMortality
All-cause mortality, Cardiovascular mortality (acute Myocardial Infarction, sudden death, heart failure, cerebrovascular, procedural), and Non-cardiovascular mortality
Time frame: Through study completion, an average of once a year, up to 20 years
Heart Failure
Congestive heart failure
Time frame: Through study completion, an average of once a year, up to 20 years
Heart and/or Lung Transplantation
Time frame: Through study completion, an average of once a year, up to 20 years
Left Ventricular and/or Right Ventricular Assist Device Implantation
Time frame: Through study completion, an average of once a year, up to 20 years
Cardiac Interventions
Implantable cardioverter-defibrillator (ICD), pacemakers, cardiac resynchronization therapy, coronary revascularization, valvular intervention, shunt closure
Time frame: Through study completion, an average of once a year, up to 20 years
Arrhythmic
Sustained ventricular tachycardia, ventricular fibrillation, nonfatal cardiac arrest, appropriate ICD therapy
Time frame: Through study completion, an average of once a year
Acute myocardial infarction
Time frame: Through study completion, an average of once a year, up to 20 years
Acute Cerebrovascular Accident
Time frame: Through study completion, an average of once a year, up to 20 years
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