This Doctor of Philosophy (PhD) project is part of a larger project on potentially modifiable risk factors for dementia in a life course perspective, with an overarching aim to improve prevention of dementia and thereby potentially relieve patient and caregiver distress and decrease societal load. The present PhD project will concentrate on confirming knowledge of HI as an independent risk factor for dementia and exploring potentially causative factors to explain this relationship.
Despite a huge increase in the knowledge about disease mechanisms in various types of dementia in recent years, no curative treatment exists at present. Results from research on disease-modifying agents have been disappointing. This has led to an increased interest in other ways to reduce the prevalence of dementia. A recent report estimated that up to one third of dementia cases could be delayed or prevented by interventions directed at the most common risk factors. In the "Lancet commission on dementia prevention, treatment, and care", hearing impairment (HI) was identified as the potentially most important modifiable risk factor. Even though HI is considered an important modifiable risk factor, the evidence regarding the association between HI and dementia risk is still limited.
Study Type
OBSERVATIONAL
Enrollment
6,952
Norwegian National Advisory Unit of Ageing and Health
Tønsberg, Norway
Rate of dementia diagnosis in the HUNT 70+ study
Two clinical and scientific experts will independently set at diagnosis of cognitive impairment or dementia based on all available information applying standard diagnostic criteria Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5).
Time frame: 2017-2019
Rate of Minimal Cognitive Impairment (MCI) in the HUNT 70+ study
Two clinical and scientific experts will independently set at diagnosis of cognitive impairment or dementia based on all available information applying standard diagnostic criteria DSM-5.
Time frame: 2017-2019
Rate of cognitive impairment defined as age- and education-adjusted thresholds on cognitive assessments scales
The participants have been assessed with the Montreal Cognitive Assessment scale and the ten-word recall test
Time frame: 2017-2019
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