Prone Position and Renal Resistive Index

University Hospital, Grenoble20 enrolled

Overview

Patients suffering from Acute Respiratory Distress Syndrome (ARDS) with a prone position (PP) indication will benefit from measurements of renal resistive index, intra-abdominal pressure (IAP), urinary oxygen tension (uPO2) and ventilatory mechanics in supine position (baseline IAP), after 2 hours in PP at the current IAP value, thirty minutes after patients' abdomen suspension in order to resume baseline IAP and after patients' are turned back to supine position.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Acute Respiratory Distress Syndrome Acute Kidney Injury Prone Position Intra-Abdominal Hypertension

Interventions

Prone positionOTHER

Abdomen suspension in prone position

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ARDS patients according to Berlin criteria, intubated, mechanically ventilated * with PaO₂/FiO₂ \< 150 mmHg, * neuromuscular blockade * with an indication of PP done by the physician in charge * possibility to differ PP for one hour * patients should be hemodynamically stable since at least 4 hours Exclusion Criteria: * Pregnant or breast-feeding women * legal protection, no social security affiliation * PP contra-indication * nasogastric tube contra-indication * extra corporeal membrane oxygenation * acute kidney injury at inclusion according to K-DIO criteria, chronic kidney disease defined as an estimated glomerualr filtration rate less than 30 ml/min/1.73m², kidney transplantation, renal artery stenosis, solitary kidney, albuminuria \> 1.25 mg/ml * cardiac arrhythmia * obesity * advanced cirrhosis

Locations (1)

Hospital Grenoble University

Grenoble, France

Outcomes

Primary Outcomes

change in renal resistive index (RRI)

RRI measurement will be performed on a right kidney arcuate/interlobar artery, with a high frequency Doppler probe. Three to five consecutive measures will be obtained then RRI computed according to the formula: (peak systolic velocity - end diastolic velocity)/peak systolic velocity).