Targeted Plasticity Therapy for Upper Limb Rehabilitation in Spinal Cord Injuries

Inclusion Criteria In order to be eligible to participate in this study, an individual must meet all of the following criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * Adult, aged 18-64 * In good general health as evidenced by medical history and diagnosed with first time cervical spinal cord injury resulting in an ASIA grade B, C, or D, and level 1 or better motor function as described by the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI). * SCI caused by trauma that occurred ≥ 12 months prior to enrollment * Meets all clinical criteria for the surgical VNS implantation as determined by the PI, surgeon, and anesthesiologist * Must demonstrate some residual upper limb and hand movement in either arm * Appropriate candidate for VNS implantation * Willing and able to comply with the study protocol Exclusion Criteria An individual who meets any of the following criteria will be excluded from participation in this study: * Spinal cord injuries by sharp objects, firearms, and non-traumatic or congenital causes, even if at different levels of the spinal cord * Any evidence of recurrent laryngeal nerve injury (Evident during required laryngoscopy for all participants with Prior right-sided anterior cervical surgery- done prior to randomization) * Excessive scar tissue marking implantation unsafe (evident at surgery) * Concomitant clinically significant brain injuries * Prior injury to vagus nerve * Prior or current treatment with vagus nerve stimulation * Participant receiving any therapy (medication or otherwise) that would interfere with VNS * Pregnancy or lactation * Clinical complications that hinder or contraindicate the surgical procedure * Psychiatric disorders, psychosocial, and/or cognitive impairment that would interfere with study participation, as assessed by medical evaluation * Abusive use of alcohol and/or illegal substances use * Participation in other interventional clinical trial * Participants with known immunodeficiency including participants who are receiving or have received chronic corticosteroids, immunosuppressants, immunostimulating agents or radiation therapy within 6 months * Significant comorbidities or conditions associated with high risk for surgical or anesthetic survival (e.g. renal failure, peripheral vascular disease, unstable cardiac disease, poorly controlled diabetes, immunosuppression, etc.). * Active neoplastic disease. * Participants with significant local circulatory problems, (e.g. thrombophlebitis and lymphedema). * Participants with any medical condition or other circumstances that might interfere with their ability to return for follow-up visits in the judgment of the Investigator, including systemic illness, neuromuscular, neurosensory, or musculoskeletal deficiency that would render the participant unable to perform appropriate postoperative rehabilitation. * Any condition which, in the judgment of the Investigator, would preclude adequate evaluation of device's safety and performance. * Aphasia and other cognitive deficits that make understanding the potential risks and benefits of the study impossible for participant. Inability to personally provide informed consent. * A recent history of syncope * A recent history of dysphagia * Currently require, or are likely to require diathermy * Significant respiratory issues that would interfere with participation * Non-English speaking * Patients who are acutely suicidal and/or have been admitted for a suicide attempt * Incarceration or legal detention