Psychological disorders characterized by impulsivity often show alterations in dorsal anterior cingulate cortex (dACC) activity. Recent research has therefore focused on non-invasive neurostimulation therapies for the modulation of functional activity in the dACC. To date there has only been one proof-of-concept study providing evidence for modulating dACC activity with non-invasive electrical neurostimulation (e.g. transcranial electrical stimulation). Since transcranial Direct Current Stimulation (tDCS) is relatively safe, tolerable, and mobile as compared to other neurostimulation techniques, it is worthwhile looking further into the effects of tDCS on functional dACC activity. The aim of the present research is to explore whether HD-tDCS can induce changes in the dACC in individuals with high trait impulsivity (N=20) in a double-blind cross-over study. Functional changes in dACC activity will be measured by the error related negativity (ERN), which is an event related potential generated by the dACC. The ERN is less pronounced in people that score high on impulsivity. It is therefore expect enhanced ERN amplitudes after HD-tDCS over the dACC. In addition, performance on the multisource interference task will be used as measure of dACC activity. It is hypothesize that increased dACC activity will be related to decreased impulsivity in high impulsive individuals as shown by improved inhibitory control on the Go/NoGo task. The results of the study may have implications for patient populations that are characterized by impulsivity.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DEVICE_FEASIBILITY
Masking
DOUBLE
Enrollment
23
TDCS is a non-invasive neuromodulation technique that modulates membrane potentials by means of small electrical currents. Electrical currents induced by tDCS electrodes produce an electrical field that modulates the excitability of brain areas. In the present HD-tDCS montage, one anodal electrode and four return electrodes are applied. Hereby, the anodal electrode modulates the excitability of the targeted area, whereas the other 4 electrodes return electrical currents that flow away from that area. Direct currents will be transmitted through 5 circular PiStim electrodes of 3.14cm2 (Neuroelectrics, Barcelona, Spain; current density=0.32 mA/cm2) with a current intensity of 1.5 mA. The HD-tDCS session will last for 20 minutes in total, with a 60 sec ramp at the beginning and end of the session. The electrodes will be filled with conductive gel and plugged into an EEG cap, with the anode placed over Fz and the four return electrodes over Fp1, Fp2, F7, and F8 (10-20 system).
For the sham-condition, the placement of the electrodes was identical to active HD-tDCS stimulation with the anode placed over Fz and the four return electrodes over Fp1, Fp2, F7, and F8 (10-20 system). The direct current, also transmitted through 5 circular PiStim electrodes of 3.14cm2 (Neuroelectrics, Barcelona, Spain; current density=0.32 mA/cm2), was increased in a ramp-like fashion over 60 seconds until it reached 1.5 mA. Directly after ramp-up, the current intensity was gradually switched off over 60 seconds, followed by 20 minutes without active stimulation. Sham procedures for tDCS mimic the transient skin sensation at the beginning of active HD-tDCS, without producing any conditioning effects on the brain. Consequently, participants are reliably blinded for sham tDCS.
Monash University, BrainPark
Melbourne, Victoria, Australia
Change in error related negativity (ERN) measured by electroencephalography (EEG) after active and sham HD-tDCS
To measure changes in electrophysiological measures of error processing after active vs. sham HD-tDCS
Time frame: Baseline, directly after (active vs. sham) HD-tDCS, and 30 min after (active vs. sham) HD-tDCS.
Change in NoGo N2 measured by electroencephalography (EEG)
To measure changes in electrophysiological measures of early inhibitory control processes after active vs. sham HD-tDCS
Time frame: Baseline, directly after (active vs. sham) HD-tDCS, and 30 min after (active vs. sham) HD-tDCS.
Change in NoGo P3 measured by electroencephalography (EEG) after active and sham HD-tDCS
To measure changes in electrophysiological measures of motor inhibitory control processes after active vs. sham HD-tDCS
Time frame: Baseline, directly after (active vs. sham) HD-tDCS, and 30 min after (active vs. sham) HD-tDCS.
Change in percentage of correct nogo trials on Go/NoGo task after active vs. sham HD-tDCS
To measure the effect of active vs. sham HD-tDCS on accuracy on trials for which responses have to be inhibited. Represents a measure of change in inhibitory control.
Time frame: Baseline, directly after (active vs. sham) HD-tDCS, and 30 min after (active vs. sham) HD-tDCS.
Change in reaction times on Go trials during Go/NoGo task after active vs. sham HD-tDCS
To measure changes in speed of motor responses during Go/NoGo task differences after active vs. sham HD-tDCS
Time frame: Baseline, directly after (active vs. sham) HD-tDCS, and 30 min after (active vs. sham) HD-tDCS.
Change in reaction times post incorrect trials during Go/NoGo task after active vs. sham HD-tDCS
To measure the effect of active vs. sham HD-tDCS on post-error slowing as behavioural measure of error processing.
Time frame: Baseline, directly after (active vs. sham) HD-tDCS, and 30 min after (active vs. sham) HD-tDCS.
Change in interference effect on multisource interference task (MSIT) after active vs. sham HD-tDCS
The interference effect is calculated by subtracting the mean reaction time for congruent trials from the mean reaction time for incongruent trials. A larger interference effect reflects worse performance and is suggested to reflect decreased dACC activity.
Time frame: Baseline, directly after (active vs. sham) HD-tDCS, and 30 min after (active vs. sham) HD-tDCS.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.