High-flow Nasal Oxygenation for Open Mouth

Seoul National University Hospital15 enrolled

Overview

This study aims to evaluate the effect of high-flow nasal oxygenation on safe apnea time for children undergoing general anesthesia, with their mouth open.

Oxygenation via high-flow nasal cannula is gaining popularity in various clinical settings. It is known to increase apnea time for apneic patients including children. However, high-flow nasal cannula is known to be ineffective when the patient's mouth is kept open. When trying to intubate the patient during induction of anesthesia, the patient should be apneic with administration of neuromuscular blocking agent, and the mouth should be open for introduction of laryngoscope. We designed a prospective randomized controlled study to evaluate the effect of high-flow nasal oxygenation in the aforementioned setting for trying to intubate the patient.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Anesthesia, General Apnea

Interventions

Apnea with high-flow nasal cannulaDEVICE

Application of oxygenation with high-flow nasal cannula with a rate of 2L/kg/min

ApneaOTHER

Apnea without any application of oxygenation

Eligibility

Sex: ALLMax age: 10 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Children younger than 11 years old scheduled to undergo surgery under general anesthesia, with American Society of Anesthesiologists Physical Status 1 or 2. Exclusion Criteria: * Refusal to enrollment from one or more of legal guardians of the patient * Children who are planned to use supraglottic airway device * Children with upper respiratory tract infection or pulmonary interstitial disease * Preterm babies under 40 weeks of postconceptual age * Children who are expected to have difficult airway for bag-mask ventilation

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Apnea time

Time required for pulse oximetry to drop to 92% after start of apnea

Time frame: Elapsed time starting from discontinuation of oxygen to the time point that pulse oximetry first reaches 92% (not to exceed 520 seconds)