Behavioral disturbances are often seen in children after anesthesia both immediately after surgery (emergence delirium) and after discharge from hospital. Persisting behavioral changes may affect emotional and cognitive development. It is known that both type of surgery and anesthetic management affect the occurrence of behavioral disturbances. Specifically, differences in occurrence were found after sevoflurane anesthesia and propofol anesthesia, two anesthetics that are generally used in practice. However, evidence is based on methodologically weak studies. The described occurrence of behavioral disturbances in children after anesthesia is not in line with the investigators' clinical experience, and neither are the described differences in occurrence between sevoflurane anesthesia and propofol anesthesia. This study will compare emergence delirium and behavioral changes after discharge from hospital in children who had surgery for removal of their tonsils under sevoflurane anesthesia versus propofol anesthesia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
761
Anesthesia is maintained with a continuous infusion of Propofol. Induction of anesthesia and anesthetic management are otherwise the same in both study arms.
Anesthesia is maintained with a continuous inhalation of Sevoflurane. Induction of anesthesia and anesthetic management are otherwise the same in both study arms.
Namsos Hospital, Nord-Trondelag Hospital Trust
Namsos, Trøndelag, Norway
ØNH Legen
Trondheim, Trøndelag, Norway
Pediatric Anesthesia Emergence Delirium Scale (PAED) ≥ 10
A PAED score ≥ 10 during the first hour after emergence from anaesthesia is defined as an ED event occuring
Time frame: 1 hour
Face, Legs, Activity, Cry, Consolability Scale (FLACC) ≥ 4
A FLACC score ≥ 4 during the first hour after emergence from anaesthesia is defined as moderate or severe pain
Time frame: 1 hour
Post Hospital Behavioral Questionnaire (PHBQ)
An average score \> 3 in one or more of the questionnaire categories is defined as postoperative behavioural change
Time frame: 7 days
Post Hospital Behavioral Questionnaire (PHBQ)
An average score \> 3 in one or more of the questionnaire categories is defined as postoperative behavioural change
Time frame: 30 days
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