A study to address the effects of early-day fasting on fat tissue mobilization in comparison to a typical isocaloric Mediterranean and a low-carbohydrate breakfast.
The study design meets a cross-over pattern with 3 different morning visits of 6 hour duration each. After an informed consent is received from the participant, a crude medical history, physical examination and collection of somatometric data through bio-impendance analysis will take place. An intravenous catheter will be placed in the participants forearm. At zero time point, depending on study visit, participants will either (A) remain fasted (B) start consuming ta pre-prepared zero-carbohydrate 500 kcal test meal (C) start consuming ta pre-prepared 500 kcal test meal with a composition conforming to a standard Mediterannean breakfast. Participants will be given 10 minutes to consume the meal. Blood samples will be drawn and visual analogue scales (VAS) for hunger and satiety will be filled in at the following time points (min): -15, 0, 15, 30, 60, 90, 120, 180, 240, 300, 360.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
10
6-hour fasting
Consumption of a zero-carbohydrate breakfast
Consumption of a Mediterranean-type breakfast
Diabetes Clinical Research Laboratory, 1st Department of Propaedeutic Internal Medicine
Athens, Greece
Mobilisation of adipose tissue
Area Under the Curve (AUC) of free fatty acid (FFA) and beta-Hydroxybutyrate (bOB) concentration
Time frame: 6 hours
Mobilisation of gut peptides
AUC of Ghrelin, Peptide YY and glucagon-like peptide -1 (GLP-1) concentration
Time frame: 6 hours
Degree of appetite suppression
Visual Analogue Scale score (0-10, 0 equals minimal and 10 equals highest) for appetite
Time frame: 6 hours
Degree of satiety induction
Visual Analogue Scale score (0-10, 0 equals minimal and 10 equals highest) for satiety
Time frame: 6 hours
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