Evaluation of the Brain and Renal Regional Oxygenation Using NIRS in Preterm Infants

Vilnius University150 enrolled

Overview

This study evaluates the brain and renal oxygenation using near infrared spectroscopy in preterm infants with persistent ductus arteriosus

Patent ductus arteriosus (PDA) is common in preterm infants. In the presence of a large PDA, significant systemic to pulmonary shunting occurs, which may result in pulmonary hyperperfusion and systemic hypoperfusion. The evidence on PDA effect on brain and renal tissue oxygenation, measured by Near Infrared Spectroscopy is still controversial. This study aims to evaluate the brain and renal oxygenation using near infrared spectroscopy (NONIN SenSmart model X-100) in 3 groups of preterm infants: 1) closed ductus arteriosus, 2) persistent ductus arteriosus, 3) hemodynamicaly significant ductus arteriosus.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Pre-Term Persistent Ductus Arteriosus

Interventions

NONIN SenSmart model X-100 near- infrared spectrometerDEVICE

for to measure cerebral (cSO2) and renal (rSO2 ) regional tissue oxygen saturation on the day after echocardiography was done. The sensors were placed on the right/left forehead and the right/left lateral posterior flank

Eligibility

Sex: ALLMin age: 22 WeeksMax age: 32 Weeks

Medical Language ↔ Plain English

Inclusion Criteria: * preterm infants with gestation age of \< 32 weeks * birth weight \< 1500g * \> 72 hours of age. Exclusion Criteria: * cardiovascular, renal, cerebral congenital defects, * confirmed sepsis, * no parental consent

Locations (1)

Vilnius University Santaros Klinikos Neonatology Center

Vilnius, Lithuania

Outcomes

Primary Outcomes

Differences of the mean values of regional oxygenation of the brain and renal

Cerebral and renal regional tissue oxygen saturation monitoring on the day after echocardiography was done

Time frame: from Day 4 of live up to 36 weeks

Data from ClinicalTrials.gov

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