This trial gathers information from patients with primary central nervous system or base of skull tumors that receive proton beam therapy and see if certain imaging techniques can help detect radiation-related changes over time. This study may help providers learn more about proton beam radiotherapy and how to improve the way it is delivered.
PRIMARY OBJECTIVE: I. To establish linear energy transfer (LET)-based models as early predictors for white matter changes on magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) sequences in pediatric patients following proton beam therapy for primary central nervous system (CNS) and base of skull tumors. OUTLINE: Patients' medical charts are reviewed.
Study Type
OBSERVATIONAL
Enrollment
36
Review of medical chart
Mayo Clinic in Arizona
Scottsdale, Arizona, United States
White matter changes within the central nervous system (CNS) following proton beam therapy using magnetic resonance imaging (MRI) sequences
The concordance of predicted linear energy transfer linear (LET) values with radiographic white matter changes will be analyzed utilizing a one sample t-test. Will the compare concordance over time to evaluate if there is an increase, utilizing repeated measures mixtures models.
Time frame: At 18 months
White matter changes within the CNS following proton beam therapy using diffusion tensor imaging (DTI) sequences
The concordance of predicted LET values with radiographic white matter changes will be analyzed utilizing a one sample t-test. We will the compare concordance over time to evaluate if there is an increase, utilizing repeated measures mixtures models.
Time frame: At 18 months
Relative biological effectiveness (RBE) predictions
Will compare concordance over time to evaluate if there is an increase, utilizing repeated measures mixtures models.
Time frame: Up to 18 months
White matter changes within the CNS following proton beam therapy using DTI and MRI
Will assess the white matter changes within the CNS following proton beam therapy using DTI and MRI and determine concordance with predicted RBE values and biological dose.
Time frame: Up to 18 months
Dose-volume effect and predicted LET distribution
Will be correlated. Will evaluate the percent of concordance of isodose volumes with white matter changes utilizing pairwise t-tests and repeated measures mixed models.
Time frame: Up to 18 months
White matter changes identified on imaging, and predict concordance
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Will be described with both clinical acute and late toxicities following proton beam therapy. Exploratory analyses utilizing tests for association and appropriate regression techniques will be conducted to determine the association of dose volume histogram, LET, RBE, and clinical factors on acute and late toxicities caused by white matter changes.
Time frame: Up to 18 months