The purpose of the study is to determine the intra-articular concentration of vancomycin and tobramycin after administration of vancomycin and tobramycin powder in primary cementless total knee arthroplasty and determine the serum concentrations of these antibiotics postoperatively.
Patients will be identified by medical record review to make sure they meet inclusion and exclusion criteria. Patients that qualify and sign consent will have tobramycin and vancomycin antibiotic powder placed into the knee during surgery. Postoperative drain fluid from the knee will be collected.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Everyone gets tobramycin powder.
Everyone gets the vancomyscin powder.
Washington University School of Medicine
St Louis, Missouri, United States
Concentration of Antibiotics in Cementless Knees Post op
1\. Determine the intra-articular concentration of vancomycin and tobramycin after administration of vancomycin and tobramycin powder in primary cementless total knee arthroplasty.
Time frame: 1 hour, 4 hours, and 24 hours
Serum Concentrations of Vancomycin and Tobramycin at 1, 4, and 24 Hours.
2\. Determine the serum concentrations of these antibiotics postoperatively
Time frame: 1 hour, 4 hours, and 24 hours
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