Neurological Fate, Prematurity and Genetic Susceptibility Factors

Nantes University Hospital27 enrolled

Overview

This study could help identify aggravating or protective genetic polymorphisms associated with cerebral palsy. Populations of premature babies at different risk of cerebral palsy could thus be individualized with an impact on their monitoring and on the pathophysiological understanding of the processes leading to neurological lesions.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Polymorphism, Restriction Fragment Length Premature Infertility of Cervical Origin

Interventions

no interventionOTHER

no intervention

Eligibility

Sex: ALLMin age: 5 YearsMax age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: * children born prematurely at term \<34 weeks between 2008 and 2015 * assessed at the age of 2 within the Growing Together Network in Pays de Loire * parental consent for the collection of data from their child and for intraoral sampling for the search for genetic factors. Exclusion Criteria: * children who died after the age of 2 * children who refused and / or whose parents refused to participate in the study

Locations (1)

CHU Nantes

Nantes, France

Outcomes

Primary Outcomes

Identify a polymorphism associated with the risk of developing cerebral palsy at 2 years in a regional population of premature infants of gestational age <34 weeks gestation.

frequency of variants within the case and control groups using the statistical criterion "level of significance" (also called p-value and known by the English word "p-value") of 5.10-8

Time frame: 2 years

Secondary Outcomes

Identify a specific polymorphism of certain forms of cerebral palsy

neurological examination

Time frame: 2 years

Develop a prognosis algorithm for the occurrence of cerebral palsy for personalized monitoring in a population at risk.

neurological examination

Time frame: 2 years

Data from ClinicalTrials.gov

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