Frontline Lenalidomide for AL Amyloidosis Involving Myocardium

Inclusion Criteria: * Age more than 19 years old * Amyloid light-chain amyloidosis patients who meet both(A and B) of the following criteria A. Cardiac involvement: meet one or more of the following criteria 1. Echocardiography : mean wall thickness \> 12mm, and no other cardiac cause 2. Cardiac MRI : CMR was considered positive for amyloid cardiomyopathy if there were morphologic and structural abnormalities consistent with the diagnosis (wall thickening of the left ventricular \[LV\], right ventricular \[RV\], or interatrial septum and biatrial enlargement) coupled with abnormal myocardial nulling and diffuse or irregular delayed gadolinium enhancement of the LV myocardium. 3. N-terminal prohormone of brain natriuretic peptide : \> 332ng/l in the absence pf renal failure B. Exposure history to lenalidomide: participants should have never been exposed to lenalidomide within 5 years. * Eastern Cooperative Oncology Group performance status ≤ 3 * Patients must meet the following clinical laboratory criteria with 2 weeks of starting treatment: 1. Serum creatinine ≤ 3.0mg/dl or Creatinine Clearance ≥ 50ml/minute (Cockcroft-Gault) 2. Absolute neutrophil count ≥ 1000/ul 3. Platelet ≥ 75,000/ul 4. Hemoglobin ≥ 8.0mg/dl 5. Bilirubin \< 2 times or Alkaline phosphate \< 4 times upper limit of normal * At least 3 months of existence are expected from the time of enroll this study * A female of childbearing potential(is defined as a sexually mature woman who: 1 has not undergone a hysterectomy or bilateral oophorectomy or 2, has not been naturally post-menopausal (amenorrhea following cancer therapy does not rule out childbearing potential) must have a negative pregnancy test prior to treatment. 1. must agree to use two reliable methods of contraception simultaneously or practice complete abstinence from any heterosexual intercourse during the following time periods related to this study: for at least 4 weeks after study treatment discontinuation. 2. must have two(serum and urine) negative pregnancy test during screening period 3. must have serum and urine negative pregnancy test within 10-14 days and 24hrs before commencing lenalidomide * Male patients who agree to practice effective barrier contraception during the entire study treatment period and through 30 days after the last dose of study treatment * Patients who understand and voluntarily agree to the contents of the research statement in writing and who are willing and able to comply with the visit schedule, treatment plan, laboratory examination and other testing procedures Exclusion Criteria: * Amyloid light-chain amyloidosis without cardiac involvement * Patients who are planning to receive autologous stem cell transplantation or received autologous stem cell transplantation, remained in hematologic complete response * Pregnant, lactating or unwilling to use adequate contraception * Male patients who unwilling to practice effective barrier contraception during the entire study treatment period and through 30 days after the last dose of study treatment * Patients with acute infections requiring nonpermanent therapy (antibiotics, antibacterial drugs, or antiviral drugs) within 14 days of the first administration of the lenalidomide or with a history of systemic fungal infections and infections without valid antimicrobial agents * Any clinically significant history of genetic, kidney, neurological, psychiatric, endocrine, metabolism, immunological, cardiovascular, lung, or liver diseases in the investigator's opinion, may interfere with protocol adherence or a patient's ability to give informed consent. * Patients with known history of allergic and hypersensitivity for investigational product, their analogous bodies, or the subtypes contained in the various forms of any preparation * Patients who were given a live vaccine within 8 weeks of the first dose of the drug * Chemotherapy with approved or investigation anticancer therapeutics within 4 weeks prior to starting this study * Patients who are unable to voluntarily agree to participate in a study or who are not willing to participate