Repetitive Transcranial Magnetic Stimulation (rTMS) for Dystonia and Tremor

University of Florida12 enrolled

Overview

The study will include subjects diagnosed with Dystonic Tremor (DT), Essential Tremor (ET), and healthy controls in the age range of 21-80 years. Electroencephalography (EEG) will be used as the primary outcome measure. Transcranial Magnetic Stimulation (TMS) will be used over the motor cortices or cerebellar cortices as an intervention that is expected to have short-term (less than an hour) electrophysiological effects.

The primary goal of this study is to compare differences in cortical activity of patients with tremor before and after applying a session of rTMS. Specifically, the investigators will apply rTMS to the primary motor cortex (M1) as our group and others have shown abnormal function of the region. Moreover, a study shows that targeting of M1 and the dorsal premotor cortex (dPMC) with rTMS results in a trend towards improved clinical outcome in patients with focal hand dystonia and cervical dystonia. The central hypothesis of this study is that rTMS can modify cortical oscillations in patient populations with tremor and that the investigators will be able to detect these changes with the use of Electroencephalography (EEG). By applying inhibitory rTMS to the motor cortices, the investigators may expect a shift in cortical oscillations towards normal activity.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Dystonia Tremor

Interventions

repetitive Transcranial Magnetic Stimulation (rTMS)DEVICE

Repetitive transcranial magnetic stimulation (rTMS) is a form of brain stimulation therapy using a magnet to target and stimulate certain areas of the brain.

Control groupOTHER

No application of rTMS

Eligibility

Sex: ALLMin age: 21 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria for Dystonia and/or tremor: \- Diagnosis of Dystonia and/or tremor according to the Consensus Statement of the Movement Disorders Society Exclusion Criteria Dystonia and/or tremor: * Pregnancy * Active seizure disorder * Presence of a metallic object such as a pacemaker, implants, metal rods, and hearing aid * History of stroke Inclusion Criteria for Healthy controls \- There is no history of any neurological disorders. Exclusion Criteria for Healthy controls * Pregnancy * Any neurological disorders * Presence of a metallic body in their brain * History of stroke

Locations (1)

University of Florida

Gainesville, Florida, United States

Outcomes

Primary Outcomes

Cognitive Assessment Using MoCA Version 7.1 Scores

Montreal Cognitive Assessment Version 7.1 was used to assess cognitive ability. This scales is score from a range of 0 to 30 with a score of 24 or less indicating mild cognitive impairment. Moderate cognitive impairment is indicated by a score of 18-23 and severe impairment is a score of 10 or less. Overall, a higher number indicates better cognitive ability.

Time frame: Day 1

Data from ClinicalTrials.gov

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