High absorption pad for blood and pus with natural antimicrobial agent or gauze dressing impregnated with paraffin, containing 0.5% chlorhexidine acetate (Bactigras) will be randomly covered on half of split-thickness skin graft donor site wound. The another will be cover on another half of split-thickness skin graft donor site wound. Then, they will be covered with gauzes and bandage. Time to wound healing, amounts of covered dressing gauzes, signs of infection, pain score, erythema index, melanin index, trans epidermal water loss index, and adverse events will be evaluated.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
24
High absorption pad for blood and pus will be covered on half of split-thickness skin graft donor site wound until the wound has healed.
Commercial wound dressing will be covered on half of split-thickness skin graft donor site wound until the wound has healed.
Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn Unviersity
Bangkok, Thailand
wound healing time
The day that the dressing will detach without painful.
Time frame: not more than 28 days
amounts of secondary gauze dressing
The amounts of secondary gauze dressing that will be changed because of blood over capacity.
Time frame: not more than 28 days
pain score
Pain score will be evaluated using visual analogue scale. The 0 and 10 scores mean no pain and very pain, respectively. Higher score means more painful.
Time frame: 5 days after donor site wound was created
signs of infection
Signs of infection mean pain, swollen, red, and warn including pus on the wound.
Time frame: not more than 28 days
scar melanin index
Scar melanin index will be measured using Cutometer (Mexameter). There is no unit. Higher value mean higher risk of post inflammatory reaction.
Time frame: 3 months
scar erythema index
Scar erythema index will be measured using Cutometer (Mexameter). There is no unit. Higher value mean higher risk of post inflammatory reaction.
Time frame: 3 months
transepidermal water loss index
Transepidermal water loss index of scar will be measured using Cutometer (Tewameter). There is no unit. Higher value mean higher risk of unhealthy scar.
Time frame: 3 months
scar quality
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Scar quality will be evaluated using vancouver scar scale. The 0 and 13 scores mean high scar quality and low scar quality , respectively. Higher score means low scar quality.
Time frame: 3 months
adverse events
Adverse events will be observed. They will be recorded as "present" or "not present".
Time frame: not more than 28 days
aspartate aminotransferase in serum
Aspartate aminotransferase in serum (in U/L) after treatment will not be more than before treatment.
Time frame: not more than 28 days
alanine aminotransferase in serum
Alanine aminotransferase in serum (in U/L) after treatment will not be more than before treatment.
Time frame: not more than 28 days
blood urea nitrogen
Blood urea nitrogen (in mg/dl) after treatment will not be more than before treatment.
Time frame: not more than 28 days
serum creatinine
Serum creatinine (in mg/dl) after treatment will not be more than before treatment.
Time frame: not more than 28 days