Inflammatory mediators in periodontitis may lead to elevated systemic cytokine levels, resulting in increased bone resorption including the jaws. Osteoporosis may have an influence on the periodontal condition of post-menopausal women and the risk for periodontal disease may increase due to osteoporosis. The hypothesis of the study was that non-surgical periodontal treatment and medical treatment of osteoporosis by bisphosphonates may improve the clinical outcomes and decrease salivary levels of IL-1β, IL-17, ALP and 8-OHdG. Therefore, the aim of this study was to evaluate the mechanism of bi-directional relationship between osteoporosis and periodontal diseases and to investigate the outcomes of non-surgical periodontal treatment with regard to salivary levels of IL-1β, IL-17, 8-OHdG and ALP in patients with periodontitis and osteoporosis.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
75
supra- and subgingival scaling, and root planning
Gazi University
Ankara, Cankaya, Turkey (Türkiye)
salivary levels of IL-1β at baseline
evaluation of the salivary levels of IL-1β in g/ml
Time frame: baseline
salivary levels of IL-1β at 1-month
evaluation of the salivary levels of IL-1β in g/ml
Time frame: 1-month follow-up after non-surgical periodontal therapy
salivary levels of IL-1β at 3-month
evaluation of the salivary levels of IL-1β in g/ml
Time frame: 3-month follow-up after non-surgical periodontal therapy
salivary levels of IL-17 baseline
evaluation of the salivary levels of IL-17 in g/ml
Time frame: baseline
salivary levels of IL-17 at 1-month
evaluation of the salivary levels of IL-17 in g/ml
Time frame: 1-month follow-up after non-surgical periodontal therapy
salivary levels of IL-17 at 3-month
evaluation of the salivary levels of IL-17 in g/ml
Time frame: 3-month follow-up after non-surgical periodontal therapy
salivary levels of alkaline phosphatase at baseline
evaluation of the salivary levels of alkaline phosphatase in g/ml
Time frame: baseline
salivary levels of alkaline phosphatase at 1-month
evaluation of the salivary levels of alkaline phosphatase in g/ml
Time frame: 1-month follow-up after non-surgical periodontal therapy
salivary levels of alkaline phosphatase at 3-month
evaluation of the salivary levels of alkaline phosphatase in g/ml
Time frame: 3-month follow-up after non-surgical periodontal therapy
salivary levels of 8-hydroxydeoxyguanosine at baseline
evaluation of the salivary levels of 8-hydroxydeoxyguanosine in g/ml
Time frame: baseline
salivary levels of 8-hydroxydeoxyguanosine at 1-month
evaluation of the salivary levels of 8-hydroxydeoxyguanosine in g/ml
Time frame: 1-month follow-up after non-surgical periodontal therapy
salivary levels of 8-hydroxydeoxyguanosine at 3-month
evaluation of the salivary levels of 8-hydroxydeoxyguanosine in g/ml
Time frame: 3-month follow-up after non-surgical periodontal therapy
Plaque index
Plaque index scores assessed at baseline and at 1 month and 3 months after non-surgical periodontal therapy
Time frame: baseline, 1- and 3-month follow- up.
gingival index
gingival index scores assessed at baseline and at 1 month and 3 months after non-surgical periodontal therapy
Time frame: baseline, 1- and 3-month follow- up.
bleeding on probing
bleeding on probing scores assessed at baseline and at 1 month and 3 months after non-surgical periodontal therapy
Time frame: baseline, 1- and 3-month follow- up.
probing depth
probing depth scores assessed at baseline and at 1 month and 3 months after non-surgical periodontal therapy
Time frame: baseline, 1- and 3-month follow- up.
clinical attachment level
clinical attachment level scores assessed at baseline and at 1 month and 3 months after non-surgical periodontal therapy
Time frame: baseline, 1- and 3-month follow- up.
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