Strategies to Maintain Radial Artery Patency Following Diagnostic Coronary Angiography - Diagnostic Transradial Coronary Angiography Without Systemic Anticoagulatio

N/AUnknownNCT04301921

Prof. Dr. med. Ingo Eitel400 enrolled

Overview

To investigate whether omitting systemic anticoagulation during transradial coronary angiography and/or a distal radial access reduce the risk of postprocedural radial artery occlusion

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

400

Conditions

Patients Undergoing Diagnostic Coronary Angiography

Interventions

Traditional punkcture site and No anticoagulationOTHER

Traditional punkcture site and No anticoagulation

Traditional punkcture site and ACT-guided anticoagulationOTHER

Traditional punkcture site and ACT-guided anticoagulation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical indication to perform diagnostic coronary angiography * Age \> 18 years * Written informed consent Exclusion Criteria: * Preexisting or already administered anticoagulation prior to coronary angiography * Planned coronary intervention * Preexisting radial artery occlusion or missing pulse at the potential puncture sites * Allergy / intolerance to anticoagulants * Active bleeding or comorbidity with elevated bleeding risk * Pregnancy * Inability to sign informed consent * Participation in another trial

Outcomes

Primary Outcomes

Occurrence of postprocedural RAO

Will be the occurrence of postprocedural RAO assessed with high-resolution vascular ultrasound. Experienced sonographers will perform color Doppler ultrasound in all study patients after removal of the compression device to examine the radial, ulnar, and brachial arteries of the access forearm.

Time frame: Day 1

Bleeding events

Will be bleeding events according to Bleeding Academic Research Consortium (BARC) criteria.

Time frame: Day 1

Secondary Outcomes

Sonographic characteristics of radial artery occlusion

Occlusion lengths or minimal residual perfusion

Time frame: 3 Month

Data from ClinicalTrials.gov

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