Patient Acceptance and Preference Among Screening Modalities for Detection of Barrett's Esophagus

Inclusion Criteria: * Patients with one of the following: Gastroesophageal Reflux Disease (GERD) OR Barrett's esophagus (BE) * At least 18 years of age at time of consent * Able and willing to provide written informed consent * Able and willing to comply with required study procedures and follow-up schedule * Presenting to UNC Hospitals for routine care upper endoscopy Exclusion Criteria: * History of pre-existing esophageal stenosis/ stricture, esophageal diverticulum or significant esophageal anatomic abnormalities (masses, obstructive lesions, etc.) * History of head and neck malignancy or anatomical abnormalities of the nasopharynx * Any history of Ear, Nose and Throat (ENT) surgery * History of significant epistaxis or hereditary hemorrhagic telangiectasia (HHT) * Sinus or pulmonary infection in the last 4 weeks * Current use of blood thinners such as coumadin, warfarin, clopidogrel, heparin and/or low molecular weight heparin (requires discontinuation of medication 7 days prior to and 7 days after esophagogastroduodenoscopy \[EGD\] and Cytosponge administration, aspirin use is OK). * Known bleeding disorder * Pregnancy, or planned pregnancy during the course of the study. * Any history of esophageal varices, liver impairment of moderate or worse severity (Child's- Pugh class B \& C) or evidence of varices noted on any past endoscopy * Any history of esophageal surgery, except for uncomplicated fundoplication * History of coagulopathy, with international normalised ratio (INR) \>1.3 and/or platelet count of \<75,000 * General poor health, multiple co-morbidities placing the patient at risk, or otherwise unsuitable for trial participation * Subject has any condition that, in the opinion of the investigator or sponsor, would interfere with accurate interpretation of the study objectives or preclude participation in the trial