Pharmacokinetics of Islatravir in Participants With Severe Renal Impairment (MK-8591-026)

Inclusion Criteria: Healthy participants must have the following: * Is in good health * Has a body mass index (BMI) ≥18.5 and ≤40 kg/m2. * Female is not pregnant or breastfeeding, and is not one of the following: a woman of childbearing potential (WOCBP); if a WOCBP, is using an acceptable contraceptive method, or is abstinent from heterosexual intercourse as their preferred and usual lifestyle; a WOCBP must have a negative highly sensitive pregnancy test within 24 hours before the first dose of study intervention Renally impaired participants must have the following: * With the exception of renal impairment, is in generally good health * Has a BMI ≥ 18.5 and ≤ 40 kg/m2 * Female is not pregnant or breastfeeding, and is not one of the following: a woman of childbearing potential (WOCBP); if a WOCBP, is using an acceptable contraceptive method, or is abstinent from heterosexual intercourse as their preferred and usual lifestyle; a WOCBP must have a negative highly sensitive pregnancy test within 24 hours before the first dose of study intervention Exclusion Criteria: Healthy participants must have the following: * Has a history of clinically significant endocrine, gastrointestinal, cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases. * Is mentally or legally incapacitated, has significant emotional problems * Has known hypersensitivity to the active substance or any of the excipients of the study drug * Has a history of significant multiple and/or severe allergies (e.g. food, drug, latex allergy), or has had an anaphylactic reaction or significant intolerability (i.e. systemic allergic reaction) to prescription or non-prescription drugs or food. * Is positive for hepatitis B surface antigen, hepatitis C antibodies or HIV. * Had major surgery, donated or lost 1 unit of blood (approximately 500 mL) within prior 4 weeks * Is taking medications to treat chronic medical conditions and/or conditions associated with renal disease * Has participated in another investigational study within prior 4 weeks Other exclusions for healthy participants: * Does not agree to follow the smoking restrictions * Consumes greater than 1 glass for women, or 2 glasses for men of alcoholic beverages per day * Consumes excessive amounts,of caffeinated beverages per day. * Is a regular user of cannabis, any illicit drugs or has a history of drug (including alcohol) abuse within approximately prior 3 months. Renally impaired participants must have the following: * Has a history or presence of renal artery stenosis. * Has had a renal transplant or nephrectomy. * Has rapidly fluctuating renal function as determined by historical measurements. * Has known hypersensitivity to the active substance or any of the excipients of the study drug. * Has a history of cancer (malignancy). * Has a history of significant multiple and/or severe allergies (e.g. food, drug, latex allergy), or has had an anaphylactic reaction or significant intolerability (i.e. systemic allergic reaction) to prescription or non-prescription drugs or food. * Is positive for hepatitis B surface antigen, hepatitis C antibodies or human immunodeficiency virus (HIV). * Had major surgery, donated or lost 1 unit of blood (approximately 500 mL) within 4 weeks prior to the prestudy (screening) visit. * Is taking medications to treat chronic medical conditions and/or conditions associated with renal disease and has not been on a stable regimen for at least 1 month and/or is unable to withhold the use of the medication(s) within 4 hours prior to and 8 hours after administration of the study drug. * Has participated in another investigational study within 4 weeks (or 5 half-lives, whichever is greater) prior to the prestudy (screening) visit. Other exclusions for renally impaired participants * Does not agree to follow the smoking restrictions. * Consumes greater than 1 glass for women, or 2 glasses for men of alcoholic beverages per day. * Consumes excessive amounts of caffeinated beverages per day. * Is a regular user of cannabis, any illicit drugs or has a history of drug (including alcohol) abuse within approximately 3 months.