A randomized control trial studying the effect of prophylactic antibiotics to reduce surgical site infections following cardiac surgery in adults using 1st generation cephalosporin (Cefazolin) or 2nd generation cephalosporin (Cefuroxime).
A prospective randomized controlled patient blinded study with 2x2 factional design. It aims to study optimal duration of antibiotic to reduce surgical site infections following cardiac surgery in adults 24 or 48 hours using 1st generation cephalosporin (Cefazolin) or 2nd generation cephalosporin (Cefuroxime). Patients shall remain on either medicines for 24 or 48 hours. The primary endpoints of the study are:(1) 48 hours antibiotic prophylaxis is superior to 24 hours in adult cardiac surgery (2) Cefuroxime is superior to Cafazolin as a prophylactic antibiotic in adult cardiac surgery. Secondary endpoints include; organisms causing surgical site infections, length of hospital and ICU stay, and worsening in renal function.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
568
second generation cephalosporin
First generation cephalosporin
Duration of antibiotic therapy
Saud AlBabtain Cardiac Center
Dammam, Eastern Province, Saudi Arabia
surgical site infection rate is less with Cefuroxime than Cefazolin
that Second Generation Cefalosporin is superior to first generation
Time frame: within 3 months from date of surgery
surgical site infection rate is less with 48 hours rather than 24 hours
That Longer duration of prophylaxis is better than shorter duration
Time frame: within 3 months from date of surgery
Length of actual Hospital Stay in the group assigned to 48 hours of cefuroxime
that 48 hours of cefuroxime will reduce hospital stay
Time frame: within 3 months from date of surgery
Length of ICU Stay will be shorter in the group assigned to 48 hours of cefuroxime
that 48 hours of cefuroxime will reduce ICU stay
Time frame: within 3 months from date of surgery
rate of infection with a specific organism following each of the antibiotics used
type of organism following each type of antibiotic used
Time frame: within 3 months from date of surgery
change from baseline of serum creatinine for each antibiotic used
that 48 hours of cefuroxime will not worsen renal function
Time frame: within 3 months from date of surgery
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Duration of antibiotic therapy